Selectfluor → HCID 178526427, Verbindung

To a solution of 6-bromo-4-nitro-1H-indazole (5 g) in acetonitrile (50 ml) and acetic acid (10 ml) was added Selectfluor (9.39 g). The resulting mixture was heated to 100° C. and stirred for two days. The reaction mixture was concentrated under vacuum. The residue was dissolved in DCM and then filtered off. The sample was absorbed onto silica powder then solid loaded onto the companion where it was purified on a 120 g silica column using a 0-100% ethyl acetate:cyclohexane gradient. The appropriate fractions were combined and concentrated to yield the title compound as an orange solid, 2 g.

1. concentrationThe reaction mixture was concentrated under vacuum
2. dissolutionThe residue was dissolved in DCM
3. filtrationfiltered off
4. customThe sample was absorbed onto silica powder
5. customwas purified on a 120 g silica column
6. concentrationconcentrated

ORD-Eintrag

ord-d3a1492b7bc947e9896a67d40edb8d5d

Quelldatensatz

uspto-grants-2016_05

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US09326987B2