9-Nitro-5,6-dihydro-benzo[f]quinoline → 9-Amino-5,6-dihydro-benzo[f]quinoline

HRID 521002Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 521002
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]2[CH2:16][CH2:15][C:14]3[N:13]=[CH:12][CH:11]=[CH:10][C:9]=3[C:8]=2[CH:17]=1)([O-])=O>[Pd].CO>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]2[CH2:16][CH2:15][C:14]3[N:13]=[CH:12][CH:11]=[CH:10][C:9]=3[C:8]=2[CH:17]=1

Komponenten

4

Edukt 1

HCID 582946079-Nitro-5,6-dihydro-benzo[f]quinoline

Produkt 1

HCID 582945549-Amino-5,6-dihydro-benzo[f]quinoline

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

A mixture of 9-nitro-5,6-dihydro-benzo[f]quinoline (1.90 g), 10% palladium on carbon (0.20 g), and methanol (10 mL) is shaken under hydrogen atmosphere (3 bar) at room temperature for 3 h. The catalyst is then separated by filtration and the filtrate is concentrated to give an oil that is submitted to the next reaction without further purification. Yield: 1.67 g (crude); Mass spectrum (ESI+): m/z=197 [M+H]+.

Aufarbeitung

  1. customThe catalyst is then separated by filtration
  2. concentrationthe filtrate is concentrated
  3. customto give an oil that
  4. customis submitted to the next reaction without further purification

Quellen und Nachweise

ORD-Eintrag
ord-1860cece45ed4101ad0a6eec5f174ffc
Quelldatensatz
uspto-grants-2016_05
Patentnummer
US09328072B2

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