Butyryl chloride → N-[4-(4-Piperidinomethyl-2-pyridyloxy)-cis-2-butenyl]-2-(2-butyryloxyethylthio)acetamide

HRID 52120

Reaktionsgleichung

Reaktionsgleichung von HRID 52120
[N:1]1([CH2:7][C:8]2[CH:13]=[CH:12][N:11]=[C:10]([O:14][CH2:15]/[CH:16]=[CH:17]\[CH2:18][NH:19][C:20](=[O:26])[CH2:21][S:22][CH2:23][CH2:24][OH:25])[CH:9]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[C:27](Cl)(=[O:31])[CH2:28][CH2:29][CH3:30]>>[N:1]1([CH2:7][C:8]2[CH:13]=[CH:12][N:11]=[C:10]([O:14][CH2:15]/[CH:16]=[CH:17]\[CH2:18][NH:19][C:20](=[O:26])[CH2:21][S:22][CH2:23][CH2:24][O:25][C:27](=[O:31])[CH2:28][CH2:29][CH3:30])[CH:9]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Komponenten

3

Edukt 2

HCID 8855Butyryl chlorideHCID 67725880N-[4-(4-piperidinomethyl-2-pyridyloxy)-cis-2-butenyl]-2-(2-hydroxyethylthio)acetamide

Produkt 1

HCID 67725830N-[4-(4-Piperidinomethyl-2-pyridyloxy)-cis-2-butenyl]-2-(2-butyryloxyethylthio)acetamideAusbeute 88 %

Versuchsvorschrift

Following a procedure similar to that described in Example 7, but using N-[4-(4-piperidinomethyl-2-pyridyloxy)-cis-2-butenyl]-2-(2-hydroxyethylthio)acetamide (prepared as described in Example 1) and butyryl chloride as starting materials, in relative proportions similar to those used in that Example, the title compound was obtained in an 88% yield.

Quellen und Nachweise

ORD-Eintrag
ord-6c8987d5d7ad4dd3b957641adaa52506
Quelldatensatz
uspto-grants-1997_04
Patentnummer
US05616579

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