3,4-dihydro-2H-pyran → 2H-Pyran, 2-(4-chlorobutoxy)tetrahydro-

HRID 5214

Reaktionsgleichung

Reaktionsgleichung von HRID 5214
[O:1]1[CH:6]=[CH:5][CH2:4][CH2:3][CH2:2]1.[Cl:7][CH2:8][CH2:9][CH2:10][CH2:11][OH:12]>Cl>[Cl:7][CH2:8][CH2:9][CH2:10][CH2:11][O:12][CH:6]1[CH2:5][CH2:4][CH2:3][CH2:2][O:1]1

Komponenten

4

Edukt 2

HCID 80803,4-dihydro-2H-pyranHCID 135694-Chloro-1-butanol

Produkt 1

HCID 1704882H-Pyran, 2-(4-chlorobutoxy)tetrahydro-Ausbeute 89,9 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 313Hydrochloric AcidKatalysator

Versuchsvorschrift

Dihydropyran (15.5 g) was added dropwise to a mixture of 4-chlorobutanol (20 g) and hydrochloric acid (18 M, 1 drop) at RT. The mixture was stirred for 30 min and washed with H2O (100 ml), aqueous NaHCO3 (1 M, 50 ml) and BR (50 ml). The dried liquid was heated under reduced pressure to leave the title compound as a colourless liquid (31.9 g). T.l.c. [L] Rf 0.5.

Aufarbeitung

  1. washwashed with H2O (100 ml), aqueous NaHCO3 (1 M, 50 ml) and BR (50 ml)
  2. temperatureThe dried liquid was heated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-8d888550453845d89f366f2eeaefe39f
Quelldatensatz
uspto-grants-1993_09
Patentnummer
US05243076

Verknüpfte Notizen

Wird geladen…