4-Aminostyrene → 1-(4-Vinylphenyl)-3-[3,5-bis(trifluoromethyl)phenyl]thiourea

HRID 522337

Reaktionsgleichung

Reaktionsgleichung von HRID 522337
[NH2:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[CH2:7])=[CH:4][CH:3]=1.[F:10][C:11]([F:26])([F:25])[C:12]1[CH:13]=[C:14]([N:22]=[C:23]=[S:24])[CH:15]=[C:16]([C:18]([F:21])([F:20])[F:19])[CH:17]=1>C1COCC1>[CH:6]([C:5]1[CH:8]=[CH:9][C:2]([NH:1][C:23]([NH:22][C:14]2[CH:15]=[C:16]([C:18]([F:19])([F:20])[F:21])[CH:17]=[C:12]([C:11]([F:10])([F:25])[F:26])[CH:13]=2)=[S:24])=[CH:3][CH:4]=1)=[CH2:7]

Komponenten

4

Edukt 2

HCID 737004-AminostyreneHCID 27333953,5-Bis(trifluoromethyl)phenyl isothiocyanate

Produkt 1

HCID 581124441-(4-Vinylphenyl)-3-[3,5-bis(trifluoromethyl)phenyl]thioureaAusbeute 60 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To a stirred solution of 4-aminostyrene (3.5 mmol) in dry THF (20 mL) under nitrogen was added 3,5-bis-(trifluoromethyl)phenyl isothiocyanate (3.5 mmol). The solution was refluxed overnight and then the solvent was evaporated under reduced pressure. The resulting solid residue was purified by column chromatography to yield the desired product in 60% yield.

Aufarbeitung

  1. temperatureThe solution was refluxed overnight
  2. customthe solvent was evaporated under reduced pressure
  3. customThe resulting solid residue was purified by column chromatography

Quellen und Nachweise

ORD-Eintrag
ord-3fe51d0a917048c28d43fc50b0e7264a
Quelldatensatz
uspto-grants-2016_05
Patentnummer
US09329186B2

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