Diisopropylethylamine → HCID 178461598, Verbindung

HRID 522802Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 522802
Cl[C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][NH:8]2)=[C:4]([N:11]2[CH2:16][CH2:15][O:14][CH2:13][C@H:12]2[CH3:17])[N:3]=1.C(N(C(C)C)CC)(C)C.Cl.[CH3:28][C@@H:29]1[CH2:34][O:33][CH2:32][CH2:31][NH:30]1>CC(O)CC.C(Cl)Cl>[CH3:28][C@@H:29]1[CH2:34][O:33][CH2:32][CH2:31][N:30]1[C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][NH:8]2)=[C:4]([N:11]2[CH2:16][CH2:15][O:14][CH2:13][C@H:12]2[CH3:17])[N:3]=1

Komponenten

6

Edukt 3

HCID 81531DiisopropylethylamineHCID 57356922(3R)-3-Methylmorpholine hydrochlorideHCID 178461592HCID 178461592, Verbindung

Produkt 1

HCID 178461598HCID 178461598, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6344DichloromethaneLösungsmittelHCID 6568(+-)-2-ButanolLösungsmittel

Reaktionsbedingungen

Temperatur
180 °C

Versuchsvorschrift

2-Chloro-6-((R)-3-methyl-morpholin-4-yl)-9H-purine (1.02 g, 4 mmol), diisopropylethylamine (1.40 mL, 8 mmol), and (R)-3-methylmorpholin hydrochloride (826 mg, 6 mmol) were stirred in 2-butanol (5 mL) in a closed microwave tube under argon at 50° C., until all ingredients were dissolved. The reaction was then stirred at 180° C. for 100 hours. The reaction mixture was then cooled to room temperature and diluted with 200 mL of CH2Cl2.

Aufarbeitung

  1. dissolutionwere dissolved
  2. temperatureThe reaction mixture was then cooled to room temperature

Quellen und Nachweise

ORD-Eintrag
ord-b947f4e924834d29af0e3d3298ae2880
Quelldatensatz
uspto-grants-2016_05
Patentnummer
US09334271B2

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