2-Amino-5-bromobenzenemethanol → 2-Amino-5-bromobenzaldehyde

HRID 524033

Reaktionsgleichung

Reaktionsgleichung von HRID 524033
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Br:8])=[CH:4][C:3]=1[CH2:9][OH:10]>C(Cl)Cl.O=[Mn]=O>[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Br:8])=[CH:4][C:3]=1[CH:9]=[O:10]

Komponenten

4

Edukt 1

HCID 110308742-Amino-5-bromobenzenemethanol

Produkt 1

HCID 235104752-Amino-5-bromobenzaldehydeAusbeute 81 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 14801Manganese dioxideKatalysatorHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

A mixture of (2-amino-5-bromophenyl)methanol (10 g, 49.5 mmol) and MnO2 (25.8 g, 296.6 mmol) in CH2Cl2 (400 mL) was stirred at RT overnight. LCMS showed the reaction was completed. The solid was filtered off, and the filtrate was concentrated to give the title compound as a light yellow solid (8 g, 81%), which was directly used in next step without further purification. MS (ES+) C7H6BrNO requires: 199. found: 200, 202 [M+H]+.

Aufarbeitung

  1. filtrationThe solid was filtered off
  2. concentrationthe filtrate was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-cce5a4d41af44cbe996d2618a96c8642
Quelldatensatz
uspto-grants-2016_05
Patentnummer
US09340514B2

Verknüpfte Notizen

Wird geladen…