Oxalyl chloride → 5-(Benzyloxy)-2-methylbenzoyl chloride

HRID 524320Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 524320
[CH2:1]([O:8][C:9]1[CH:10]=[CH:11][C:12]([CH3:18])=[C:13]([CH:17]=1)[C:14](O)=[O:15])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(Cl)(=O)C([Cl:22])=O>C(Cl)Cl>[CH2:1]([O:8][C:9]1[CH:10]=[CH:11][C:12]([CH3:18])=[C:13]([CH:17]=1)[C:14]([Cl:22])=[O:15])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Komponenten

4

Edukt 2

HCID 65578Oxalyl chlorideHCID 597600475-(Benzyloxy)-2-methylbenzoic acid2×

Produkt 1

HCID 866574365-(Benzyloxy)-2-methylbenzoyl chloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a mixture of 3.3 g 5-(benzyloxy)-2-methylbenzoic acid (compound F1) in 80 ml DCM are added 1.4 ml of oxaloylchloride, and the reaction is stirred at RT over night under a blanket of nitrogen. The solvent is removed under reduced pressure yielding the title compound, which was used without further purification.

Aufarbeitung

  1. customThe solvent is removed under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-2cfccea2aea04d5cab4c9ef385a394f4
Quelldatensatz
uspto-grants-2016_05
Patentnummer
US09340522B2

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