Ammonium Chloride → 5-Methyl-1,3,4-thiadiazole-2-carboximidamide hydrochloride

Reaktionsgleichung

[CH3:1][C:2]1[S:6][C:5]([C:7]#[N:8])=[N:4][N:3]=1.C[O-].[Na+].[Cl-:12].[NH4+:13]>>[ClH:12].[CH3:1][C:2]1[S:6][C:5]([C:7](=[NH:13])[NH2:8])=[N:4][N:3]=1

Komponenten

Edukt 3

HCID 25517Ammonium Chloride

HCID 10942334Sodium Methoxide

HCID 185439255-Methyl-1,3,4-thiadiazole-2-carbonitrile

Produkt 1

HCID 900429855-Methyl-1,3,4-thiadiazole-2-carboximidamide hydrochlorideAusbeute 70 %

Versuchsvorschrift

5-methyl-1,3,4-thiadiazole-2-carbonitrile (1.25 g, 10 mmol) was reacted with sodium methoxide (0.54 g, 10 mmol) and ammonium chloride (0.64 g, 12 mmol) according to the procedure as described in Example 61, Step B to give the title compound as a yellowish solid (1.25 g, 70%). The compound was characterized by the following spectroscopic data:

Quellen und Nachweise

ORD-Eintrag: ord-9f7847bf72fa422d8321bbcd3833e6bb
Quelldatensatz: uspto-grants-2016_05
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US09340538B2

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