Ammonium Chloride → 1-methyl-1H-1,2,4-triazole-3-carboximidamide hydrochloride

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Reaktionsgleichung

[CH3:1][N:2]1[CH:6]=[N:5][C:4]([C:7]#[N:8])=[N:3]1.C[O-].[Na+].[Cl-:12].[NH4+:13]>>[ClH:12].[CH3:1][N:2]1[CH:6]=[N:5][C:4]([C:7](=[NH:13])[NH2:8])=[N:3]1

Komponenten

Edukt 3

HCID 25517Ammonium Chloride

HCID 10942334Sodium Methoxide

HCID 607103171-methyl-1H-1,2,4-triazole-3-carbonitrile

Produkt 1

HCID 900441211-methyl-1H-1,2,4-triazole-3-carboximidamide hydrochlorideAusbeute 78,8 %

Versuchsvorschrift

1-methyl-1H-1,2,4-triazole-3-carbonitrile (20 g, 185 mmol) was reacted with sodium methoxide (14 g, 295 mmol) and ammonium chloride (14.8 g, 277.5 mmol) according to the procedure as described in Example 61, Step B to give the title compound as a white solid (23.44 g, 78.8%). The compound was characterized by the following spectroscopic data:

Quellen und Nachweise

ORD-Eintrag: ord-ca98bc871af843d284830ebbfdef4d73
Quelldatensatz: uspto-grants-2016_05
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US09340538B2

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