Ammonium Chloride → Methyl 2-(3-carbamimidoyl-1H-1,2,4-triazol-1-yl)acetate hydrochloride

Reaktionsgleichung

[C:1]([C:3]1[N:7]=[CH:6][N:5]([CH2:8][C:9]([O:11][CH2:12]C)=[O:10])[N:4]=1)#[N:2].C[O-].[Na+].[Cl-:17].[NH4+:18]>>[ClH:17].[C:1]([C:3]1[N:7]=[CH:6][N:5]([CH2:8][C:9]([O:11][CH3:12])=[O:10])[N:4]=1)(=[NH:2])[NH2:18]

Komponenten

Edukt 3

HCID 25517Ammonium Chloride

HCID 10942334Sodium Methoxide

HCID 60710264ethyl 2-(3-cyano-1H-1,2,4-triazol-1-yl)acetate

Produkt 1

HCID 90042811Methyl 2-(3-carbamimidoyl-1H-1,2,4-triazol-1-yl)acetate hydrochlorideAusbeute 55 %

Versuchsvorschrift

Ethyl 2-(3-cyano-1H-1,2,4-triazol-1-yl)acetate (2 g, 11.2 mmol) was reacted with sodium methoxide (0.85 g, 15.68 mmol) and ammonium chloride (0.89 g, 16.8 mmol) according to the procedure as described in Example 61, Step B to give the title compound as a white solid (1.35 g, 55%). The compound was characterized by the following spectroscopic data:

Quellen und Nachweise

ORD-Eintrag: ord-002c5003137c447c984d7d10eac4f92b
Quelldatensatz: uspto-grants-2016_05
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US09340538B2

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