Ammonium Chloride → 5-Methoxythiazole-2-carboximidamide hydrochloride

HRID 524803Notizen

Reaktionsgleichung

[CH3:1][O:2][C:3]1[S:7][C:6]([C:8]#[N:9])=[N:5][CH:4]=1.C[O-].[Na+].[Cl-:13].[NH4+:14]>>[ClH:13].[CH3:1][O:2][C:3]1[S:7][C:6]([C:8](=[NH:14])[NH2:9])=[N:5][CH:4]=1

Komponenten

Edukt 3

HCID 25517Ammonium Chloride

HCID 10942334Sodium Methoxide

HCID 900443835-Methoxythiazole-2-carbonitrile

Produkt 1

HCID 900443915-Methoxythiazole-2-carboximidamide hydrochlorideAusbeute 50,1 %

Versuchsvorschrift

5-methoxythiazole-2-carbonitrile (0.74 g, 5.26 mmol) was reacted with sodium methoxide (0.28 g, 5.26 mmol) and ammonium chloride (0.6 g, 11 mmol) according to the procedure as described in Example 61, Step B to give the title compound as a white solid (0.51 g, 50%). The compound was characterized by the following spectroscopic data:

Quellen und Nachweise

ORD-Eintrag: ord-0acb2cb2b6f34530ada9a9277acb8d23
Quelldatensatz: uspto-grants-2016_05
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US09340538B2

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