Hydrochloric Acid → 3-Amino-2-hydroxycyclohexane-1-carboxylic acid

HRID 527058

Reaktionsgleichung

Reaktionsgleichung von HRID 527058
[OH:1][C:2]1[C:10]([N+:11]([O-])=O)=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].Cl>O=[Pt]=O>[NH2:11][CH:10]1[CH2:9][CH2:8][CH2:7][CH:3]([C:4]([OH:6])=[O:5])[CH:2]1[OH:1]

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 68073-Nitrosalicylic acid

Produkt 1

HCID 672865413-Amino-2-hydroxycyclohexane-1-carboxylic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 345198Adams' catalystKatalysator

Versuchsvorschrift

2-Hydroxy-3-nitro-benzoic acid (5.0 g, 27.3 mmol) was mixed with HCl (125 mL of 0.5 M, 62.5 mmol) and dioxoplatinum (1.0 g, 4.4 mmol) in a hydrogenation bottle. The mixture was placed on a Parr shaker (50 psi H2) for 24 hours. The catalyst was filtered and washed with hot H2O. The filtrate was evaporated to provide 3-amino-2-hydroxy-cyclohexanecarboxylic acid as a mixture of stereoisomers which was utilized to the next step without further purification.

Aufarbeitung

  1. filtrationThe catalyst was filtered
  2. washwashed with hot H2O
  3. customThe filtrate was evaporated

Quellen und Nachweise

ORD-Eintrag
ord-cf6bcba6db304c449b33de6ed56e92f1
Quelldatensatz
uspto-grants-2016_05
Patentnummer
US09345708B2

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