Sodium Hydroxide → 4-(5-fluoro-2-methoxyphenyl)-6-iodo-7H-pyrrolo[2,3-d]pyrimidine

A solution of Example 3C (3.5 g, 6.78 mmol) in 70 mL dioxane was treated with aqueous sodium hydroxide (11.30 mL, 67.8 mmol, 6 M) and stirred at 100° C. for 1 hour. The reaction mixture was cooled and diluted with 300 mL of water. The aqueous mixture was extracted with ethyl acetate (3×), and the combined organic fractions were washed with brine, dried over magnesium sulfate and concentrated to give the title compound. MS (ESI+) m/z 370.1 (M+H)+.

1. temperatureThe reaction mixture was cooled
2. extractionThe aqueous mixture was extracted with ethyl acetate (3×)
3. washthe combined organic fractions were washed with brine
4. dry with materialdried over magnesium sulfate
5. concentrationconcentrated

ORD-Eintrag

ord-f0ce5eff1bd046f9a62c99e198bd1d43

Quelldatensatz

uspto-grants-2016_05

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US09346813B2