Hydrochloric Acid → N-allyl-L-aspartic acid di-tert-butyl ester hydrochloride

HRID 529208Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 529208
[C:1]([O:5][C:6](=[O:20])[C@H:7]([CH2:12][C:13]([O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:14])[NH:8][CH2:9][CH:10]=[CH2:11])([CH3:4])([CH3:3])[CH3:2].O.[ClH:22]>C(#N)C>[ClH:22].[C:1]([O:5][C:6](=[O:20])[C@H:7]([CH2:12][C:13]([O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:14])[NH:8][CH2:9][CH:10]=[CH2:11])([CH3:4])([CH3:2])[CH3:3]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 962WaterHCID 86673330N-allyl-L-aspartic acid di-tert-butyl ester

Produkt 1

HCID 86673331N-allyl-L-aspartic acid di-tert-butyl ester hydrochlorideAusbeute 95 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

To the compound (0.50 g, 1.8 mmol) obtained in step 1 were added water (17 mL) and 1N hydrochloric acid (1.8 mL, 1.8 mmol). Acetonitrile (10 ml) was added to dissolve the mixture, and the solution was concentrated under reduced pressure, and lyophilized to give the title compound (0.54 g, 1.7 mmol, 95%).

Aufarbeitung

  1. dissolutionto dissolve the mixture
  2. concentrationthe solution was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-9c7fe5a3e3b24d4d85ca86f0be782854
Quelldatensatz
uspto-grants-2016_05
Patentnummer
US09346821B2

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