Lithium Hydroxide → N-[(5-tert-butoxycarbonylthiophen-2-yl)methyl]-N-methyl-L-leucine lithium salt

HRID 529216Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 529216
C[O:2][C:3](=[O:24])[C@H:4]([CH2:20][CH:21]([CH3:23])[CH3:22])[N:5]([CH2:7][C:8]1[S:9][C:10]([C:13]([O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:14])=[CH:11][CH:12]=1)[CH3:6].[OH-].[Li+:26]>CO.O1CCCC1>[Li+:26].[C:16]([O:15][C:13]([C:10]1[S:9][C:8]([CH2:7][N:5]([CH3:6])[C@H:4]([C:3]([O-:24])=[O:2])[CH2:20][CH:21]([CH3:23])[CH3:22])=[CH:12][CH:11]=1)=[O:14])([CH3:17])([CH3:18])[CH3:19]

Komponenten

5

Edukt 2

HCID 3939Lithium HydroxideHCID 90107000N-[(5-tert-butoxycarbonylthiophen-2-yl)methyl]-N-methyl-L-leucine methyl ester

Produkt 1

HCID 90107093N-[(5-tert-butoxycarbonylthiophen-2-yl)methyl]-N-methyl-L-leucine lithium salt

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

The compound (0.87 g, 2.4 mmol) obtained in step 1 was dissolved in methanol (2.7 mL) and tetrahydrofuran (5.4 mL), 1N aqueous lithium hydroxide solution (2.7 mL) was added, and the mixture was stirred overnight. The reaction mixture was concentrated under reduced pressure, water was added, and the mixture was lyophilized to give the title compound (0.83 g).

Aufarbeitung

  1. concentrationThe reaction mixture was concentrated under reduced pressure, water
  2. additionwas added

Quellen und Nachweise

ORD-Eintrag
ord-10db9cde73e744afab8004bee3ca1c64
Quelldatensatz
uspto-grants-2016_05
Patentnummer
US09346821B2

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