Butanal → HCID 178449166, Verbindung

HRID 529279Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 529279
[CH:1](=O)[CH2:2][CH2:3][CH3:4].[C:6]1([C@@H:12]([NH2:14])[CH3:13])[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1>C(Cl)Cl>[CH:1](=[N:14]/[C@H:12]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)[CH3:13])\[CH2:2][CH2:3][CH3:4]

Komponenten

4

Edukt 2

HCID 261ButanalHCID 758181-Phenethylamine, (-)-

Produkt 1

HCID 178449166HCID 178449166, VerbindungAusbeute 102,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a suspension of 10 g 3 Å MS in CH2Cl2 (150 mL) under N2 at rt was added butyraldehyde (4.96 mL, 55 mmol) followed by (S)-(−)-1-phenylethylamine (6.45 mL, 50 mmol). The mixture was stirred at rt for 1.5 h, filtered over celite and the solvent removed under reduced pressure to give 9 g of the crude imine, which was used in the next step without further purification.

Aufarbeitung

  1. filtrationfiltered over celite
  2. customthe solvent removed under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-366a0d258e1e4ddd87dae4c8e6594639
Quelldatensatz
uspto-grants-2016_05
Patentnummer
US09346853B2

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