Hydrochloric Acid → N-Carboxymethyl-2-butyl-1-[(2'-carboxybiphenyl-4-yl)methyl]-4-hydroxymethylimidazole-5-carboxamide

HRID 52945

Reaktionsgleichung

Reaktionsgleichung von HRID 52945
C([O:5][C:6]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[C:14]1[CH:19]=[CH:18][C:17]([CH2:20][N:21]2[C:25]([C:26](ON3C(=O)CCC3=O)=[O:27])=[C:24]([CH2:36][OH:37])[N:23]=[C:22]2[CH2:38][CH2:39][CH2:40][CH3:41])=[CH:16][CH:15]=1)=[O:7])(C)(C)C.Cl.[NH2:43][CH2:44][C:45]([O:47]C(C)(C)C)=[O:46].Cl>CN(C)C1C=CN=CC=1>[C:45]([CH2:44][NH:43][C:26]([C:25]1[N:21]([CH2:20][C:17]2[CH:16]=[CH:15][C:14]([C:9]3[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=3[C:6]([OH:7])=[O:5])=[CH:19][CH:18]=2)[C:22]([CH2:38][CH2:39][CH2:40][CH3:41])=[N:23][C:24]=1[CH2:36][OH:37])=[O:27])([OH:47])=[O:46]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 2725036Glycine tert-butyl ester hydrochlorideHCID 19036239Succinimido 1-[(2'-t-butoxycarbonylbiphenyl-4-yl)methyl]-2-butyl-4-hydroxymethylimidazole-5-carboxylate

Produkt 1

HCID 19036333N-Carboxymethyl-2-butyl-1-[(2'-carboxybiphenyl-4-yl)methyl]-4-hydroxymethylimidazole-5-carboxamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 142844-(Dimethylamino)pyridineKatalysator

Versuchsvorschrift

Following a procedure similar to that described in Example 53, but using 0.32 g of succinimido 1-[(2'-t-butoxycarbonylbiphenyl-4-yl)methyl]-2-butyl-4-hydroxymethylimidazole-5-carboxylate [prepared as described in Example 52(a)], 0.11 g of t-butyl glycinate hydrochloride and 80 mg of 4-dimethylaminopyridine, 0.21 g of the hydrochloride of the title compound was obtained as an amorphous powder melting at above 110° C. (with softening).

Quellen und Nachweise

ORD-Eintrag
ord-6c9c1d274e6a474b9407eff74b7a07f8
Quelldatensatz
uspto-grants-1997_04
Patentnummer
US05616599

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