Acetonitrile → (S)-1-(3-(ethyl(methyl)carbamoyloxy)phenyl)-N,N-dimethyl-N-((S)-1-phenylethyl)ethanaminium iodide

HRID 530209Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 530209
[I-:1].[OH:2][C:3]1[CH:4]=[C:5]([C@@H:9]([N+:11]([CH3:21])([CH3:20])[C@H:12]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH3:13])[CH3:10])[CH:6]=[CH:7][CH:8]=1.[C:22](=[O:25])([O-])[O-].[K+].[K+].C1O[CH2:44][CH2:43]OCCOCCOCCOCCOC1.[C:46](#[N:48])C>>[I-:1].[CH2:43]([N:48]([CH3:46])[C:22]([O:2][C:3]1[CH:4]=[C:5]([C@@H:9]([N+:11]([CH3:21])([CH3:20])[C@H:12]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH3:13])[CH3:10])[CH:6]=[CH:7][CH:8]=1)=[O:25])[CH3:44]

Komponenten

5

Edukt 4

HCID 6342AcetonitrileHCID 11430Potassium CarbonateHCID 2855718-Crown-6HCID 86712421HCID 86712421, Verbindung2×

Produkt 1

HCID 86712425(S)-1-(3-(ethyl(methyl)carbamoyloxy)phenyl)-N,N-dimethyl-N-((S)-1-phenylethyl)ethanaminium iodide

Reaktionsbedingungen

Temperatur
60 °C

Versuchsvorschrift

Mix 7.9 g (0.02 mol) of(S)-1-(3-hydroxyphenyl)-N,N-dimethyl-N—((S)-1-phenylethyl)ethanaminium iodide (formula VIII) with 180 ml of acetonitrile, 4.1 g (0.03 mol) of potassium carbonate, 3.6 g (0.03 mol) ethyl(methyl)carbamic chloride chloride and 0.1 g 18-crown-6 at room temperature, heat it to 60° C. and react it for 12 hours. After it is cooled to room temperature, filter it and reduce the pressure to recover the solvent and receive 9.9 g of red-brown liquid to be directly used in the next reaction.

Aufarbeitung

  1. customreact it for 12 hours
  2. temperatureAfter it is cooled to room temperature
  3. filtrationfilter it
  4. customto recover the solvent
  5. customto be directly used in the next reaction

Quellen und Nachweise

ORD-Eintrag
ord-ae12098b2e464a6099429a3f82ceb0ca
Quelldatensatz
uspto-grants-2016_05
Patentnummer
US09353049B2

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