Ethanesulfonyl chloride → N-(4-bromo-6,7-dihydro-5H-cyclopenta[c]pyridin-7-yl)ethanesulfonamide
Reaktionsgleichung
[Br:1][C:2]1[C:3]2[CH2:10][CH2:9][CH:8]([NH2:11])[C:4]=2[CH:5]=[N:6][CH:7]=1.[CH2:12]([S:14](Cl)(=[O:16])=[O:15])[CH3:13]>>[Br:1][C:2]1[C:3]2[CH2:10][CH2:9][CH:8]([NH:11][S:14]([CH2:12][CH3:13])(=[O:16])=[O:15])[C:4]=2[CH:5]=[N:6][CH:7]=1Komponenten
3
Versuchsvorschrift
In analogy to the procedure described for the preparation of example 4, (rac)-4-bromo-6,7-dihydro-5H-cyclopenta[c]pyridin-7-amine (intermediate A-3 [C]) and ethanesulfonyl chloride gave the title compound as a grey solid in 94% yield. MS: 304.99 (M+H+, 1Br).
Quellen und Nachweise
- ORD-Eintrag
- ord-a1fad01e9f474baaaa8912f483f0cabd
- Quelldatensatz
- uspto-grants-2016_05
- Patentnummer
- US09353081B2
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