Einecs 211-027-4 → HCID 178431895, Verbindung

HRID 530757Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 530757
C[O:2][C:3]1[CH:8]=[C:7]([C:9]2[S:10][CH:11]=[C:12]([C:14]([F:17])([F:16])[F:15])[N:13]=2)[N:6]=[C:5]([C:18]2[S:19][CH:20]=[C:21]([CH3:23])[N:22]=2)[CH:4]=1.[Cl-].[NH+]1C=CC=CC=1>O>[CH3:23][C:21]1[N:22]=[C:18]([C:5]2[CH:4]=[C:3]([OH:2])[CH:8]=[C:7]([C:9]3[S:10][CH:11]=[C:12]([C:14]([F:16])([F:15])[F:17])[N:13]=3)[N:6]=2)[S:19][CH:20]=1

Komponenten

4

Edukt 2

HCID 69401Einecs 211-027-4HCID 681599974-Methoxy-2-(4-methyl-thiazol-2-yl)-6-(4-trifluoromethyl-thiazol-2-yl)-pyridine

Produkt 1

HCID 178431895HCID 178431895, VerbindungAusbeute 72 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
200 °C

Versuchsvorschrift

A mixture of compound 22 (1.68 mmol) and pyridinium chloride (5 g/mmol) was heated at 200° C. with stirring. After 30 min, the reaction mixture was cooled down to room temperature and H2O was added. The solid was collected, washed with H2O, and dried to give compound 23 as a grey solid in 72% yield. MS (ESI, EI+): m/z=343.85 (MH+

Aufarbeitung

  1. temperaturethe reaction mixture was cooled down to room temperature
  2. customThe solid was collected
  3. washwashed with H2O
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-079761f1ada8495e84cf02a2d56ba7ad
Quelldatensatz
uspto-grants-2016_05
Patentnummer
US09353100B2

Notizen zur Reaktion

Wird geladen…