Hydrochloric Acid → 5,6-Dimethyl-2-pyridinemethanamine

HRID 530807Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 530807
[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([C:9]#[N:10])=[N:6][C:7]=1[CH3:8].Cl.[H][H]>CO.[Pd]>[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:9][NH2:10])=[N:6][C:7]=1[CH3:8]

Komponenten

6

Edukt 3

HCID 313Hydrochloric AcidHCID 224176635,6-Dimethylpyridine-2-carbonitrileHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 450795455,6-Dimethyl-2-pyridinemethanamine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

To a solution of compound 3 in Scheme 4-3 (58 mg, 0.44 mmol) in MeOH (5 mL) and 6N HCl (1 mL) was added Pd/C (10 mg) at room temperature, the mixture was filled with hydrogen for three times and stirred overnight. The reaction mixture was filtered through celite and washed with MeOH and the filtrate was concentrated. The residue was concentrated to give compound 4 as a dark brown solid.

Aufarbeitung

  1. filtrationThe reaction mixture was filtered through celite
  2. washwashed with MeOH
  3. concentrationthe filtrate was concentrated
  4. concentrationThe residue was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-00fbc19929f245a6a70e99e326c1c017
Quelldatensatz
uspto-grants-2016_05
Patentnummer
US09353104B2

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