Lithium Hydroxide → 3-(2-methylpyridin-4-yl)-1-trityl-1H-indazole-5-carboxylic acid

HRID 530838Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 530838
[CH3:1][C:2]1[CH:7]=[C:6]([C:8]2[C:16]3[C:11](=[CH:12][CH:13]=[C:14]([C:17]([O:19]CC)=[O:18])[CH:15]=3)[N:10]([C:22]([C:35]3[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=3)([C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=3)[C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)[N:9]=2)[CH:5]=[CH:4][N:3]=1.[Li+].[OH-]>C1COCC1>[CH3:1][C:2]1[CH:7]=[C:6]([C:8]2[C:16]3[C:11](=[CH:12][CH:13]=[C:14]([C:17]([OH:19])=[O:18])[CH:15]=3)[N:10]([C:22]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)([C:35]3[CH:36]=[CH:37][CH:38]=[CH:39][CH:40]=3)[C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=3)[N:9]=2)[CH:5]=[CH:4][N:3]=1

Komponenten

4

Edukt 2

HCID 3939Lithium HydroxideHCID 67984978ethyl 3-(2-methylpyridin-4-yl)-1-trityl-1H-indazole-5-carboxylate

Produkt 1

HCID 679849753-(2-methylpyridin-4-yl)-1-trityl-1H-indazole-5-carboxylic acidAusbeute 95 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To the solution of ethyl 3-(2-methylpyridin-4-yl)-1-trityl-1H-indazole-5-carboxylate (260 mg, 0.5 mmol) in THF (5 mL) was added LiOH (1M, 2 mL). The reaction mixture was stirred at room temperature for overnight. HCL was added to adjust the pH to 4-5 and ethyl acetated was added. The extract was washed with water (10 mL0 and dry over sodium sulfate and concentrated to give the desired product in 95% yield.

Aufarbeitung

  1. additionHCL was added
  2. additionacetated was added
  3. washThe extract was washed with water (10 mL0
  4. dry with materialdry over sodium sulfate
  5. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-590d07430c904bf8a5e6146d542f6edf
Quelldatensatz
uspto-grants-2016_05
Patentnummer
US09351965B2

Notizen zur Reaktion

Wird geladen…