Trifluoroacetic acid → 5-Bromo-6-cyclopropyl-3-iodopyridin-2-amine

HRID 531445Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 531445
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([NH2:11])=[N:6][C:7]=1[CH:8]1[CH2:10][CH2:9]1.FC(F)(F)C(O)=O.[I:19]N1C(=O)CCC1=O>>[Br:1][C:2]1[CH:3]=[C:4]([I:19])[C:5]([NH2:11])=[N:6][C:7]=1[CH:8]1[CH2:9][CH2:10]1

Komponenten

4

Edukt 3

HCID 6422Trifluoroacetic acidHCID 120273N-IodosuccinimideHCID 900221395-Bromo-6-cyclopropylpyridin-2-amine

Produkt 1

HCID 900227685-Bromo-6-cyclopropyl-3-iodopyridin-2-amineAusbeute 100 %

Versuchsvorschrift

A solution of 5-bromo-6-cyclopropylpyridin-2-amine (2.1 g, 9.81 mmol), trifluoroaceticacid (170 mg, 1.47 mmol), N-iodosuccinimide (2.2 g, 9.81 mmol) stirred at room temperature for 30 minutes. Reaction mass was quenched with water, basified with ammonium hydroxide solution. Solid separated was filtered and dried to get 3.3 g (100% yield) of titled compound. 1H NMR (CDCl3, 300 MHz): δ 7.85 (s, 1H), 4.80-4.65 (bs, 2H), 2.39-2.25 (m, 1H), 1.0-0.90 (m, 4H). MS: m/z=338.9 (M+1).

Aufarbeitung

  1. customReaction mass
  2. customwas quenched with water
  3. customSolid separated
  4. filtrationwas filtered
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-1964b8422f8c46aebd9ca5d09c80cde2
Quelldatensatz
uspto-grants-2016_05
Patentnummer
US09353107B2

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