tert-Butyl 2-(5-fluoro-2-nitrophenoxy)propylcarbamate → tert-Butyl 2-(2-amino-5-fluorophenoxy)propylcarbamate

HRID 532256Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 532256
[F:1][C:2]1[CH:3]=[CH:4][C:5]([N+:20]([O-])=O)=[C:6]([CH:19]=1)[O:7][CH:8]([CH3:18])[CH2:9][NH:10][C:11](=[O:17])[O:12][C:13]([CH3:16])([CH3:15])[CH3:14]>CO.[Pd]>[NH2:20][C:5]1[CH:4]=[CH:3][C:2]([F:1])=[CH:19][C:6]=1[O:7][CH:8]([CH3:18])[CH2:9][NH:10][C:11](=[O:17])[O:12][C:13]([CH3:14])([CH3:15])[CH3:16]

Komponenten

4

Edukt 1

HCID 58413346tert-Butyl 2-(5-fluoro-2-nitrophenoxy)propylcarbamate

Produkt 1

HCID 58413393tert-Butyl 2-(2-amino-5-fluorophenoxy)propylcarbamate

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

To a solution of tert-butyl 2-(5-fluoro-2-nitrophenoxy)propylcarbamate (3.1 g) in MeOH (5 ml) was added 10% palladium on carbon (300 mg) and the reaction mixture was hydrogenated at room temperature at 50 psi. The catalyst was filtered off and the filtrate was concentrated in vacuo.

Aufarbeitung

  1. customwas hydrogenated at room temperature at 50 psi
  2. filtrationThe catalyst was filtered off
  3. concentrationthe filtrate was concentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-be0d9773c66443df96f624b4727ffac0
Quelldatensatz
uspto-grants-2014_10
Patentnummer
US08853193B2

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