Triethylamine → 4-(1H-1,2,4-Triazol-1-yl)phenyl 1,1,1-trifluoromethanesulfonate

HRID 532500

Reaktionsgleichung

Reaktionsgleichung von HRID 532500
[N:1]1([C:6]2[CH:11]=[CH:10][C:9]([OH:12])=[CH:8][CH:7]=2)[CH:5]=[N:4][CH:3]=[N:2]1.C(N(CC)CC)C.[O:20](S(C(F)(F)F)(=O)=O)[S:21]([C:24]([F:27])([F:26])[F:25])(=O)=[O:22]>ClCCl>[N:1]1([C:6]2[CH:7]=[CH:8][C:9]([O:12][S:21]([C:24]([F:27])([F:26])[F:25])(=[O:22])=[O:20])=[CH:10][CH:11]=2)[CH:5]=[N:4][CH:3]=[N:2]1

Komponenten

5

Edukt 3

HCID 8471TriethylamineHCID 67749Trifluoromethanesulfonic anhydrideHCID 1100644-(1,2,4-Triazol-1-yl)phenol

Produkt 1

HCID 866131654-(1H-1,2,4-Triazol-1-yl)phenyl 1,1,1-trifluoromethanesulfonate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

1.0 g of 4-[1,2,4]triazol-1-yl-phenol was dissolved in 10 ml of dichloromethane, and 1.72 ml of triethylamine was added thereto. 1.56 ml of Tf2O was added to the mixture and stirred for 5 hr. The reaction was terminated by using water, and the resulting mixture was extracted with dichloromethane, dried over anhydrous sodium sulfate, and concentrated under a reduced pressure to obtain the title compound.

Aufarbeitung

  1. customThe reaction was terminated
  2. extractionthe resulting mixture was extracted with dichloromethane
  3. dry with materialdried over anhydrous sodium sulfate
  4. concentrationconcentrated under a reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-0accd0b89165430a8f7a88ff3ae105a5
Quelldatensatz
uspto-grants-2014_10
Patentnummer
US08853213B2

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