Reaktionsgleichung
[C:1]([O:5][P:6]([O:13][C:14]1[CH:19]=[CH:18][C:17]([C:20]2[CH:25]=[CH:24][C:23]([CH2:26][CH2:27][C@@:28]([CH3:38])([S:34]([CH3:37])(=[O:36])=[O:35])[C:29]([O:31]CC)=[O:30])=[CH:22][CH:21]=2)=[CH:16][CH:15]=1)([O:8][C:9]([CH3:12])([CH3:11])[CH3:10])=[O:7])([CH3:4])([CH3:3])[CH3:2].BrC1N=CC(CCC(C)(S(C)(=O)=O)C(O)=O)=CC=1>>[C:9]([O:8][P:6]([O:13][C:14]1[CH:19]=[CH:18][C:17]([C:20]2[CH:21]=[CH:22][C:23]([CH2:26][CH2:27][C@@:28]([CH3:38])([S:34]([CH3:37])(=[O:35])=[O:36])[C:29]([OH:31])=[O:30])=[CH:24][CH:25]=2)=[CH:16][CH:15]=1)([O:5][C:1]([CH3:4])([CH3:3])[CH3:2])=[O:7])([CH3:10])([CH3:11])[CH3:12]Komponenten
3
Versuchsvorschrift
The title compound (4.44 g, 81%) was prepared from ethyl(2R)-4-{4′-[(di-tert-butoxyphosphoryl)oxy]biphenyl-4-yl}-2-methyl-2-(methylsulfonyl)butanoate (5.8 g, 10.2 mmol) by following a procedure analogous to that described for the preparation of 4-(6-bromopyridin-3-yl)-2-methyl-2-(methylsulfonyl)butanoic acid (i.e. Example 3, Step D). MS (LCMS) m/z 539.5 (M−1). 1H NMR (400 MHz, CHLOROFORM-d) δ ppm 1.53-1.57 (m, 18H) 1.69 (s, 3H) 2.09-2.18 (m, 1H) 2.38-2.53 (m, 2H) 2.62-2.73 (m, 1H) 3.05 (s, 3H) 7.10 (d, J=8.20 Hz, 2H) 7.25-7.37 (m, 4H) 7.45-7.51 (m, 2H).
Quellen und Nachweise
- ORD-Eintrag
- ord-f03c9f41c73c45ed9952b4a66168786b
- Quelldatensatz
- uspto-grants-2014_10
- Patentnummer
- US08853258B2
Verknüpfte Notizen
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