Formamide → Formamide

HRID 53363

Reaktionsgleichung

Reaktionsgleichung von HRID 53363
[C:1]([CH2:4][CH:5]([CH3:10])[C:6]([O:8][CH3:9])=[O:7])(=[O:3])[NH2:2].[CH:11](N)=[O:12].C[O-].[Na+].S(=O)(=O)(O)O>>[CH3:10][CH:5]([CH2:4][C:1]([O:12][CH3:11])=[O:3])[C:6]([O:8][CH3:9])=[O:7].[CH:1]([NH2:2])=[O:3]

Komponenten

6

Edukt 4

HCID 713FormamideHCID 1118Sulfuric AcidHCID 10942334Sodium MethoxideHCID 11768702Methyl 3-carbamoylisobutyrate

Produkt 2

HCID 713FormamideHCID 15350Butanedioic acid, 2-methyl-, 1,4-dimethyl ester

Versuchsvorschrift

A one L stainless steel-made autoclave equipped with a stirrer was charged with 72.5 g of the methyl 3-carbamoylisobutyrate which had been obtained in the preceding item (2), 180 g of methyl formate, 96 g of methanol and 1.1 g of sodium methylate to proceed with heating reaction at 60° C. for 2 hours. The reaction product was cooled and then analyzed. As a result, the conversion of the methyl 3-carbamoylisobutyrate was 83.2% and, there were obtained dimethyl methylsuccinate at a selectivity of 99.8% based on the reacted methyl 3-carbamoylisobutyrate, and formamide at a selectivity of 98.4% based on the same. The sodium methylate in the reaction liquid was neutralized with sulfuric acid, and subsequently the reaction liquid was distilled by a conventional method. As a result, methyl formate and methanol were recovered and there were obtained 60 g of dimethyl methylsuccinate with at least 99% purity and 16 g of formamide with 99% purity. The recovery of these substances inclusive of an intermediate fraction was quantitative, respectively.

Aufarbeitung

  1. customsubsequently the reaction liquid
  2. distillationwas distilled by a conventional method
  3. customAs a result, methyl formate and methanol were recovered

Quellen und Nachweise

ORD-Eintrag
ord-f419fd2893ef45fb8f0259106ff5352c
Quelldatensatz
uspto-grants-1997_04
Patentnummer
US05618953

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