Aluminium lithium hydride → 3-(3-methoxy-phenyl)-N,N,2-trimethyl pentylamine

HRID 533681Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 533681
[H-].[Al+3].[Li+].[H-].[H-].[H-].[CH3:7][N:8]([CH3:24])[C:9](=O)[CH:10]([CH3:22])[CH:11]([C:14]1[CH:19]=[CH:18][CH:17]=[C:16]([O:20][CH3:21])[CH:15]=1)[CH2:12][CH3:13]>CCOCC>[CH3:21][O:20][C:16]1[CH:15]=[C:14]([CH:11]([CH2:12][CH3:13])[CH:10]([CH3:22])[CH2:9][N:8]([CH3:24])[CH3:7])[CH:19]=[CH:18][CH:17]=1

Komponenten

4

Edukt 2

HCID 21226445Aluminium lithium hydrideHCID 67306944Benzenepropanamide, beta-ethyl-3-methoxy-N,N,alpha-trimethyl-

Produkt 1

HCID 223770203-(3-methoxy-phenyl)-N,N,2-trimethyl pentylamineAusbeute 85 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel

Versuchsvorschrift

The steps are: add anhydrous ether into a reaction flask, and add lithium aluminum hydride under the condition of ice bath; dip compound 7, control the temperature within 10, after the dipping detect the reaction process by TLC; after the reaction is ended, pour the reaction liquid in the ice water slowly, separate the ether layer out, rinse by water, perform drying, and recycle the solvent by decompression to obtain a light yellow liquid, 3-(3-methoxy-phenyl)-N,N,2-trimethyl pentylamine. Yield: 85%.

Aufarbeitung

  1. additionpour
  2. customseparate the ether layer out,
  3. washrinse by water
  4. customperform drying

Quellen und Nachweise

ORD-Eintrag
ord-674a2d66e96a4881858494af3ccc1fb6
Quelldatensatz
uspto-grants-2014_10
Patentnummer
US08853393B2

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