Hydrochloric Acid → HCID 86718436, Verbindung

HRID 535312Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 535312
[I:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:11]2[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][CH:12]=2)(O)[CH3:9])=[CH:4][CH:3]=1.C(OC(=O)C)(=O)C.Cl>>[I:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]([C:11]2[CH:12]=[CH:13][C:14]([O:17][CH3:18])=[CH:15][CH:16]=2)=[CH2:9])=[CH:6][CH:7]=1

Komponenten

4

Edukt 3

HCID 313Hydrochloric AcidHCID 7918Acetic AnhydrideHCID 71145508HCID 71145508, Verbindung

Produkt 1

HCID 86718436HCID 86718436, Verbindung

Versuchsvorschrift

The side chain used in example 5 (1-(4-iodophenyl)-1-(4-methoxyphenyl)ethanol) (1.25 g, 2.86 mmol) was treated with acetic anhydride (13.49 ml, 143 mmol) and HCl conc (1.042 ml, 34.3 mmol) and the reaction mixture was stirred at room temperature overnight. The reaction mixture was filtered. The precipitate was washed well with n-heptane then dried in vacuo to obtain the title compound as white solid.

Aufarbeitung

  1. filtrationThe reaction mixture was filtered
  2. washThe precipitate was washed well with n-heptane
  3. customthen dried in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-cb69c39dcf5b474c9fec2c3cbd483d58
Quelldatensatz
uspto-grants-2014_10
Patentnummer
US08859535B2

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