Sodium Carbonate → 5-Bromo-2-chloro-6-(N,N-dimethylamino)-4-methylpyridine-3-carboxamide

HRID 53542Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 53542
[Br:1][C:2]1[C:3]([CH3:14])=[C:4]([C:12]#[N:13])[C:5]([Cl:11])=[N:6][C:7]=1[N:8]([CH3:10])[CH3:9].C(=O)([O-])[O-:16].[Na+].[Na+]>S(=O)(=O)(O)O.O>[Br:1][C:2]1[C:3]([CH3:14])=[C:4]([C:12]([NH2:13])=[O:16])[C:5]([Cl:11])=[N:6][C:7]=1[N:8]([CH3:9])[CH3:10]

Komponenten

5

Edukt 2

HCID 10340Sodium CarbonateHCID 199600285-bromo-2-chloro-3-cyano-6-(N,N-dimethylamino)-4-methylpyridine

Produkt 1

HCID 199600805-Bromo-2-chloro-6-(N,N-dimethylamino)-4-methylpyridine-3-carboxamide

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 1118Sulfuric AcidLösungsmittel

Versuchsvorschrift

A solution of 5-bromo-2-chloro-3-cyano-6-(N,N-dimethylamino)-4-methylpyridine (1.3 g) in concentrated sulfuric acid (3 mL) was heated at 120° C. for 10 minutes. The mixture was cooled, diluted with water (50 mL), and neutralized with saturated sodium carbonate. After extraction with methylene chloride, evaporation of the organic phase gave 1.37 g of the title compound, suitable for use in the next reaction.

Aufarbeitung

  1. temperatureThe mixture was cooled
  2. extractionAfter extraction
  3. customwith methylene chloride, evaporation of the organic phase

Quellen und Nachweise

ORD-Eintrag
ord-c19a768d91a2451cbbbb8117fdd94cca
Quelldatensatz
uspto-grants-1997_04
Patentnummer
US05620974

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