Water → Methyl 2-amino-5-[(1-methoxy-2-methylindolizin-3-yl)carbonyl]benzoate

HRID 535441

Reaktionsgleichung

Reaktionsgleichung von HRID 535441
[CH3:1]I.[Na].[NH2:4][C:5]1[CH:13]=[CH:12][C:11]([C:14]([C:16]2[N:24]3[C:19]([CH:20]=[CH:21][CH:22]=[CH:23]3)=[C:18]([O:25][CH3:26])[C:17]=2[CH3:27])=[O:15])=[CH:10][C:6]=1[C:7]([OH:9])=[O:8].O>CN(C=O)C>[NH2:4][C:5]1[CH:13]=[CH:12][C:11]([C:14]([C:16]2[N:24]3[C:19]([CH:20]=[CH:21][CH:22]=[CH:23]3)=[C:18]([O:25][CH3:26])[C:17]=2[CH3:27])=[O:15])=[CH:10][C:6]=1[C:7]([O:9][CH3:1])=[O:8]

Komponenten

6

Edukt 4

HCID 962WaterHCID 6328Methyl iodideHCID 5360545SodiumHCID 113478952-Amino-5-[(1-Methoxy-2-Methylindolizin-3-Yl)carbonyl]benzoic Acid

Produkt 1

HCID 66653263Methyl 2-amino-5-[(1-methoxy-2-methylindolizin-3-yl)carbonyl]benzoate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

1.51 ml (24.26 mmol) of methyl iodide are added, under an inert atmosphere at ambient temperature, to 8 g (23.1 mmol) of the sodium salt of 2-amino-5-[(1-methoxy-2-methylindolizin-3-yl)carbonyl]benzoic acid (described in WO 03/084956) in 130 ml of DMF. After stirring for 1 hour, water is added. The precipitate formed is filtered off, rinsed with water, and then dried under reduced pressure at 50° C. overnight. 7.17 g of a yellow solid are obtained.

Aufarbeitung

  1. customThe precipitate formed
  2. filtrationis filtered off
  3. washrinsed with water
  4. customdried under reduced pressure at 50° C. overnight

Quellen und Nachweise

ORD-Eintrag
ord-946809f534a0476a88d787154b73908a
Quelldatensatz
uspto-grants-2014_10
Patentnummer
US08859544B2

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