Hydrochloric Acid → 5-Methoxy-3-methoxycarbonylmethyl-indan-1-yl-ammonium chloride

HRID 536636Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 536636
[CH3:1][O:2][C:3](=[O:18])[CH2:4][CH:5]1[C:13]2[C:8](=[CH:9][CH:10]=[C:11]([O:14][CH3:15])[CH:12]=2)[C:7](=[N:16]O)[CH2:6]1.[ClH:19]>[Pd].CO>[Cl-:19].[CH3:15][O:14][C:11]1[CH:12]=[C:13]2[C:8](=[CH:9][CH:10]=1)[CH:7]([NH3+:16])[CH2:6][CH:5]2[CH2:4][C:3]([O:2][CH3:1])=[O:18]

Komponenten

5

Edukt 2

HCID 313Hydrochloric AcidHCID 86650493(3-Hydroxyimino-6-methoxy-indan-1-yl)-acetic acid methyl ester

Produkt 1

HCID 866562075-Methoxy-3-methoxycarbonylmethyl-indan-1-yl-ammonium chloride

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

A mixture of 10% palladium on carbon (3.0 g), (3-hydroxyimino-6-methoxy-indan-1-yl)-acetic acid methyl ester (12.5 g), and concentrated hydrochloric acid (4.7 mL) in methanol (150 mL) is stirred under hydrogen atmosphere at room temperature overnight. The mixture is filtered and the filtrate is concentrated under reduced pressure. The residue is azeotropically dried using toluene and washed with diisopropylether to give the product as a white solid after drying at 50° C.

Aufarbeitung

  1. filtrationThe mixture is filtered
  2. concentrationthe filtrate is concentrated under reduced pressure
  3. customThe residue is azeotropically dried
  4. washwashed with diisopropylether

Quellen und Nachweise

ORD-Eintrag
ord-8c65e05a468e4c91a5f8a0a309f50f68
Quelldatensatz
uspto-grants-2014_10
Patentnummer
US08859580B2

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