Dichloromethane → (3-Methoxyphenoxy)acetyl chloride

HRID 537291Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 537291
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:11]=[CH:12][CH:13]=1)[O:6][CH2:7][C:8](O)=[O:9].C(Cl)[Cl:15].C(Cl)(=O)C(Cl)=O>CN(C=O)C>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:11]=[CH:12][CH:13]=1)[O:6][CH2:7][C:8]([Cl:15])=[O:9]

Komponenten

5

Edukt 3

HCID 6344DichloromethaneHCID 65578Oxalyl chlorideHCID 749692-(3-Methoxyphenoxy)acetic acid

Produkt 1

HCID 13612584(3-Methoxyphenoxy)acetyl chlorideAusbeute 100 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

A 500 mL flask fitted with a stir-bar, addition funnel, and an Ar inlet was charged with 3-methoxyphenoxyacetic acid (20.0 g, 110 mmol), CH2Cl2 (120 mL), and DMF (0.2 mL). Oxalyl chloride (2M in CH2Cl2, 69 mL, 137 mmol) was added to the resultant solution over 45 min forming an orange solution. The mixture stirred overnight at rt. The solution was concentrated in vacuo to give 22.7 g of 47b as an orange oil (100%). HPLC analysis (15:10:75 H2O:A1:MeOH) showed a purity of 93% with a retention time of 3.9 min.

Aufarbeitung

  1. customA 500 mL flask fitted with a stir-bar, addition funnel
  2. customforming an orange solution
  3. concentrationThe solution was concentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-ffefdc7e48074c7a8af0fb02bf679686
Quelldatensatz
uspto-grants-2014_10
Patentnummer
US08859780B2

Notizen zur Reaktion

Wird geladen…