Acetic Anhydride → N-(4-fluoro-2-(trifluoromethyl)phenyl)acetamide

HRID 53775

Reaktionsgleichung

Reaktionsgleichung von HRID 53775
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[C:9]([F:12])([F:11])[F:10].[C:13](OC(=O)C)(=[O:15])[CH3:14]>>[C:13]([NH:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[C:9]([F:12])([F:10])[F:11])(=[O:15])[CH3:14]

Komponenten

3

Edukt 2

HCID 7918Acetic AnhydrideHCID 678534-Fluoro-2-(trifluoromethyl)aniline

Produkt 1

HCID 10560920N-(4-fluoro-2-(trifluoromethyl)phenyl)acetamideAusbeute 98 %

Versuchsvorschrift

A solution of 2-amino-5-fluorobenzotrifluoride (2.025 g, 11.31 mmol, Aldrich) in acetic anhydride (10 mL) was stirred at room temperature for 12 h, and then most of the acetic anhydride was removed. The white needle crystals were collected by filtration, affording 2.445 g (98%) of 2-acetamido-5-fluorobenzotrifluoride. 1H NMR (CDCl3): δ 2.205 (S, 3H); 7.229-7.335 (m, 3H); 8.055 (dd, 1H, J1 =4.8 Hz, J2 =8.4 Hz).

Aufarbeitung

  1. custommost of the acetic anhydride was removed
  2. filtrationThe white needle crystals were collected by filtration

Quellen und Nachweise

ORD-Eintrag
ord-a4fc415634834fa4b50ffb1937ce7782
Quelldatensatz
uspto-grants-1997_04
Patentnummer
US05620979

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