Hydrochloric Acid → 1-(4-Nitrophenyl)piperidine-4-carboxylic acid

HRID 538010

Reaktionsgleichung

Reaktionsgleichung von HRID 538010
C([O:3][C:4]([CH:6]1[CH2:11][CH2:10][N:9]([C:12]2[CH:17]=[CH:16][C:15]([N+:18]([O-:20])=[O:19])=[CH:14][CH:13]=2)[CH2:8][CH2:7]1)=[O:5])C.[OH-].[Na+].O.Cl>C(O)C>[N+:18]([C:15]1[CH:16]=[CH:17][C:12]([N:9]2[CH2:8][CH2:7][CH:6]([C:4]([OH:5])=[O:3])[CH2:11][CH2:10]2)=[CH:13][CH:14]=1)([O-:20])=[O:19]

Komponenten

6

Edukt 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 14798Sodium HydroxideHCID 2796870ethyl 1-(4-nitrophenyl)piperidine-4-carboxylate

Produkt 1

HCID 27672651-(4-Nitrophenyl)piperidine-4-carboxylic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

The 1-(4-nitrophenyl)piperidine-4-carboxylic acid ethyl ester (2.78 g, 10 mmol) obtained in Example 2(1) was dissolved in ethanol (10 ml), and a 4 N sodium hydroxide aqueous solution (5 ml, 20 mmol) was added thereto. The mixture was refluxed under heat for 1 hour. After cooling to room temperature, water (30 ml) and 2 N hydrochloric acid (10 ml) were added to the mixture, and the precipitate was collected by filtration, thereby obtaining 1-(4-nitrophenyl)piperidine-4-carboxylic acid (2.47 g, 97%) as a yellow solid.

Aufarbeitung

  1. temperatureThe mixture was refluxed
  2. temperatureunder heat for 1 hour
  3. filtrationthe precipitate was collected by filtration

Quellen und Nachweise

ORD-Eintrag
ord-f4bc4f9fbd12403eaa63cc651dd93051
Quelldatensatz
uspto-grants-2014_10
Patentnummer
US08865714B2

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