Water → 5,6-Dichloro-1,3-Dihydro-2H-Benzimidazol-2-One

HRID 538106

Reaktionsgleichung

Reaktionsgleichung von HRID 538106
[Cl:1][C:2]1[CH:3]=[C:4]([NH2:10])[C:5]([NH2:9])=[CH:6][C:7]=1[Cl:8].O.CN([CH:15]=[O:16])C>>[Cl:1][C:2]1[C:7]([Cl:8])=[CH:6][C:5]2[NH:9][C:15](=[O:16])[NH:10][C:4]=2[CH:3]=1

Komponenten

4

Edukt 3

HCID 962WaterHCID 6228DimethylformamideHCID 792974,5-Dichloro-1,2-phenylenediamine

Produkt 1

HCID 98991485,6-Dichloro-1,3-Dihydro-2H-Benzimidazol-2-OneAusbeute 90 %

Versuchsvorschrift

To the solution of 4,5-dichloro-benzene-1,2-diamine (25 g, 0.14 mol) in dry DMF (200 mL), was added CU (23 g, 0.14 mol) as the solid. The reaction solution was stirred at room temperature for 1 hour, then water (500 mL) was added. The precipitated solid was collected by filtration, washed with water, dried thoroughly to afford the titled compound (26.0 g, 90%). The crude product was used in the following reaction without further purification.

Aufarbeitung

  1. filtrationThe precipitated solid was collected by filtration
  2. washwashed with water
  3. customdried thoroughly

Quellen und Nachweise

ORD-Eintrag
ord-891c32985b8f4bc0b967981e0cff0a9f
Quelldatensatz
uspto-grants-2014_10
Patentnummer
US08865713B2

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