Oxalyl chloride → 4-Fluorobenzoyl isocyanate

HRID 538415

Reaktionsgleichung

Reaktionsgleichung von HRID 538415
[F:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([NH2:8])=[O:7])=[CH:4][CH:3]=1.C(Cl)(=O)[C:12](Cl)=[O:13]>C(Cl)Cl>[F:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([N:8]=[C:12]=[O:13])=[O:7])=[CH:4][CH:3]=1

Komponenten

4

Edukt 2

HCID 65578Oxalyl chlorideHCID 715724-Fluorobenzamide

Produkt 1

HCID 27333754-Fluorobenzoyl isocyanateAusbeute 100,9 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Reaktionsbedingungen

Temperatur
50 °C

Versuchsvorschrift

To a solution of 4-fluorobenzamide (1 g, 7.2 mmol) in DCM (25 mL) was added slowly oxalylchloride (0.76 mL, 8.62 mmol). The mixture was heated to 50° C. for ˜18 hr. The mixture was allowed to cool to room temperature and concentrated in vacuo to afford crude 4-fluorobenzoyl isocyanate (1.2 g). The crude material was used in the next step without further purification.

Aufarbeitung

  1. temperatureto cool to room temperature
  2. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-2036fb3f31d74ad28e98521a32791a68
Quelldatensatz
uspto-grants-2014_10
Patentnummer
US08865732B2

Verknüpfte Notizen

Wird geladen…