Hydrochloric Acid → 2-(Pyrimidin-4-yl)nicotinic acid dihydrochloride
Reaktionsgleichung
[N:1]1[CH:6]=[CH:5][C:4]([C:7]2[N:16]=[CH:15][CH:14]=[CH:13][C:8]=2[C:9]([O:11]C)=[O:10])=[N:3][CH:2]=1.[ClH:17]>C(O)(=O)C>[ClH:17].[ClH:17].[N:1]1[CH:6]=[CH:5][C:4]([C:7]2[N:16]=[CH:15][CH:14]=[CH:13][C:8]=2[C:9]([OH:11])=[O:10])=[N:3][CH:2]=1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
A mixture of methyl 2-(pyrimidin-4-yl)nicotinate (0.19 g), acetic acid (1.0 mL) and 6 N hydrochloric acid (5 mL) was heated under reflux for 5 hr. The solvent was evaporated under reduced pressure to give the title compound (0.26 g).
Aufarbeitung
- temperaturewas heated
- temperatureunder reflux for 5 hr
- customThe solvent was evaporated under reduced pressure
Quellen und Nachweise
- ORD-Eintrag
- ord-702c976e0ec047969c665b53f0edb4ab
- Quelldatensatz
- uspto-grants-2014_10
- Patentnummer
- US08865717B2
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