Water → 2-(5-Oxazolyl)benzoic Acid

HRID 538477Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 538477
[O:1]1[C:5]([C:6]2[CH:15]=[CH:14][CH:13]=[CH:12][C:7]=2[C:8]([O:10]C)=[O:9])=[CH:4][N:3]=[CH:2]1.[OH-].[Na+].O>C1COCC1>[O:1]1[C:5]([C:6]2[CH:15]=[CH:14][CH:13]=[CH:12][C:7]=2[C:8]([OH:10])=[O:9])=[CH:4][N:3]=[CH:2]1

Komponenten

5

Edukt 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 73553912Methyl 2-(5-Oxazolyl)benzoate

Produkt 1

HCID 533937912-(5-Oxazolyl)benzoic AcidAusbeute 88,6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To a solution of methyl 2-(1,3-oxazol-5-yl)benzoate (4.0 g) in THF (40 mL) was added 2 N aqueous sodium hydroxide solution (20 mL), and the mixture was stirred at room temperature stirred for 2 days. To the reaction mixture was added water, and the mixture was washed with tert-butyl methyl ether. The pH of the obtained aqueous layer was adjusted to 2 with 2N hydrochloric acid, and the mixture was extracted with ethyl acetate. The extract was washed with saturated brine, and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure. The residue was washed with ethyl acetate/petroleum ether to give the title compound (3.3 g).

Aufarbeitung

  1. stirringstirred for 2 days
  2. washthe mixture was washed with tert-butyl methyl ether
  3. extractionthe mixture was extracted with ethyl acetate
  4. washThe extract was washed with saturated brine
  5. dry with materialdried over anhydrous sodium sulfate
  6. customThe solvent was evaporated under reduced pressure
  7. washThe residue was washed with ethyl acetate/petroleum ether

Quellen und Nachweise

ORD-Eintrag
ord-58b8e672d3ed4d748ff1d4b2e75afd13
Quelldatensatz
uspto-grants-2014_10
Patentnummer
US08865717B2

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