Acetic Acid → N-Acetyl-L-proline

HRID 538952

Reaktionsgleichung

Reaktionsgleichung von HRID 538952
[NH:1]1[CH2:8][CH2:7][CH2:6][C@H:2]1[C:3]([OH:5])=[O:4].[C:9](O)(=[O:11])[CH3:10]>>[C:9]([N:1]1[CH2:8][CH2:7][CH2:6][C@H:2]1[C:3]([OH:5])=[O:4])(=[O:11])[CH3:10]

Komponenten

3

Edukt 2

HCID 176Acetic AcidHCID 145742L-Proline

Produkt 1

HCID 66141N-Acetyl-L-prolineAusbeute 82,5 %

Reaktionsbedingungen

Temperatur
150 °C

Versuchsvorschrift

Proline (1 g, 8.68 mmol) and acetic acid (20 mL) were mixed together and heated at 150° C. in a microwave for two hours. The excess acetic acid was removed using a rotary evaporator. The residue was stirred in MTBE at ambient temperature until a solid precipitated. The mixture was filtered and the solid was washed with MTBE. The solid was dried in a vacuum oven at 60° C. The product was obtained as a white solid (1.12 g, 82.5%). 1H NMR (500 MHz, DMSO-d6) δ ppm 1.77-1.95 (m, 4H), 1.97 (s, 2H), 2.0-2.19 (m, 1H), 3.35 (dt, 1H), 3.41-3.58 (m, 2H), 4.19 (dd, 1H).

Aufarbeitung

  1. customThe excess acetic acid was removed
  2. customa rotary evaporator
  3. customprecipitated
  4. filtrationThe mixture was filtered
  5. washthe solid was washed with MTBE
  6. customThe solid was dried in a vacuum oven at 60° C

Quellen und Nachweise

ORD-Eintrag
ord-6ed644f87871434daf97c199c235ef07
Quelldatensatz
uspto-grants-2014_10
Patentnummer
US08865920B2

Verknüpfte Notizen

Wird geladen…