Hydrochloric Acid → Zantac

HRID 53911

Reaktionsgleichung

Reaktionsgleichung von HRID 53911
[CH3:1][N:2]([CH2:4][C:5]1[O:9][C:8]([CH2:10][S:11][CH2:12][CH2:13][NH:14][C:15]([NH:20][CH3:21])=[CH:16][N+:17]([O-:19])=[O:18])=[CH:7][CH:6]=1)[CH3:3].[ClH:22].C1(C)C=CC=CC=1>C(O)(C)C>[CH3:21][NH:20][C:15]([NH:14][CH2:13][CH2:12][S:11][CH2:10][C:8]1[O:9][C:5]([CH2:4][N:2]([CH3:1])[CH3:3])=[CH:6][CH:7]=1)=[CH:16][N+:17]([O-:19])=[O:18].[ClH:22]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 1140TolueneHCID 5039Ranisen

Produkt 1

HCID 47909Zantac

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3776IsopropanolLösungsmittel

Versuchsvorschrift

N-[2-[[[5-(Dimethylamino)methyl-2-furanyl]methyl]thio]ethyl]-N'-methyl-2-nitro-1,1-ethenediamine (5 g) was dissolved in isopropanol (40 ml) containing molar equivalent of hydrogen chloride. Toluene (20 ml) was added slowly to the solution. It was further stirred for 1 hr. Form 1 ranitidine hydrochloride crystallized during this period. The product was filtered off, washed with toluene (20 ml) and was dried at 45° C. under vacuum to give Form 1 ranitidine hydrochloride (5.08 g), m.p. 137°-138° C., DSC peak temperature=143.1° C., purity=99.7% (HPLC).

Aufarbeitung

  1. customForm 1 ranitidine hydrochloride crystallized during this period
  2. filtrationThe product was filtered off
  3. washwashed with toluene (20 ml)
  4. customwas dried at 45° C. under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-0841530950d5431c8af5de878923a881
Quelldatensatz
uspto-grants-1997_04
Patentnummer
US05621120

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