StartseiteMCPWorkbenchSkills
StartseiteWorkbenchBenachrichtigungenMein Bereich
llms.txt · MCP-AnleitungDatenschutz · Nutzungsbedingungen · Supportv1.8.0
  1. Startseite
  2. /Reaktion

2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl → 3-(1-(2,6-diisopropylphenyl)-1H-imidazol-2-yl)-N-(3-(isoquinolin-1-yl)phenyl)-N-phenylaniline

HRID 539479
Notizen
Druckvorschau

Reaktionsgleichung

Reaktionsgleichung von HRID 539479
[C:1]1([C:11]2[CH:12]=[C:13]([CH:21]=[CH:22][CH:23]=2)[NH:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][N:2]=1.Br[C:25]1[CH:26]=[C:27]([C:31]2[N:32]([C:36]3[C:41]([CH:42]([CH3:44])[CH3:43])=[CH:40][CH:39]=[CH:38][C:37]=3[CH:45]([CH3:47])[CH3:46])[CH:33]=[CH:34][N:35]=2)[CH:28]=[CH:29][CH:30]=1.CC(C)([O-])C.[Na+].C1(P(C2CCCCC2)C2C=CC=CC=2C2C(OC)=CC=CC=2OC)CCCCC1>C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.[Pd].[Pd].C1(C)C=CC=CC=1>[CH:45]([C:37]1[CH:38]=[CH:39][CH:40]=[C:41]([CH:42]([CH3:44])[CH3:43])[C:36]=1[N:32]1[CH:33]=[CH:34][N:35]=[C:31]1[C:27]1[CH:26]=[C:25]([CH:30]=[CH:29][CH:28]=1)[N:14]([C:13]1[CH:21]=[CH:22][CH:23]=[C:11]([C:1]2[C:10]3[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=3)[CH:4]=[CH:3][N:2]=2)[CH:12]=1)[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)([CH3:47])[CH3:46]
KomponentenVersuchsvorschriftAufarbeitungQuellen und NachweiseNotizen zur Reaktion

Komponenten

7

Edukt 4

HCID 112698722-Dicyclohexylphosphino-2',6'-dimethoxybiphenylHCID 23676156Sodium t-butoxideHCID 706542932-(3-bromophenyl)-1-(2,6-diisopropylphenyl)-1H-imidazoleHCID 706542973-(isoquinolin-1-yl)-N-phenylaniline

Produkt 1

HCID 706546753-(1-(2,6-diisopropylphenyl)-1H-imidazol-2-yl)-N-(3-(isoquinolin-1-yl)phenyl)-N-phenylaniline
Ausbeute 78 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 9811564Bis(dibenzylideneacetone)palladiumKatalysatorHCID 1140TolueneLösungsmittel

Versuchsvorschrift

3-(isoquinolin-1-yl)-N-phenylaniline (1.65 g, 5.57 mmol), 2-(3-bromophenyl)-1-(2,6-diisopropylphenyl)-1H-imidazole (2.256 g, 5.89 mmol), sodium tert-butoxide (0.802 g, 8.35 mmol), Pd2dba3 (0.102 g, 0.111 mmol) and 2-dicyclohexylphosphino-2′,6′-dimethoxybiphenyl (S-Phos) (0.184 g, 0.449 mmol) were charged into the reaction vessel with 150 mL of toluene. This mixture was evacuated and back-filled with nitrogen. The reaction mixture was then heated to reflux for 18 h. The reaction mixture was cooled to room temperature then was diluted with 75 mL of water. This mixture was then filtered through a pad of Celite®. The toluene layer was separated and dried over magnesium sulfate. The organics were filtered and stripped under vacuum. The crude residue was passed through a silica gel column using 2-40% ethyl acetate/DCM yielding 3-(1-(2,6-diisopropylphenyl)-1H-imidazol-2-yl)-N-(3-(isoquinolin-1-yl)phenyl)-N-phenylaniline (2.60 g, 4.34 mmol, 78% yield).

Aufarbeitung

  1. customThis mixture was evacuated
  2. additionback-filled with nitrogen
  3. temperatureThe reaction mixture was then heated
  4. temperatureto reflux for 18 h
  5. additionthen was diluted with 75 mL of water
  6. filtrationThis mixture was then filtered through a pad of Celite®
  7. customThe toluene layer was separated
  8. dry with materialdried over magnesium sulfate
  9. filtrationThe organics were filtered

Quellen und Nachweise

ORD-Eintrag
ord-804cc5cd3e8e4596a3b283c067834141
Quelldatensatz
uspto-grants-2014_10
DOI
10.6084/m9.figshare.5104873.v1
Patentnummer
US08871361B2

Notizen zur Reaktion

Wird geladen…

Auf dieser SeiteKomponentenVersuchsvorschriftAufarbeitungQuellen und NachweiseNotizen zur Reaktion