Methanol → 6-Benzyl-2-oxa-6-azaspiro[3.4]octan-8-amine

HRID 539982Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 539982
[CH2:1]([N:8]1[CH2:15][CH:14]([N+:16]([O-])=O)[C:10]2([CH2:13][O:12][CH2:11]2)[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl-].[NH4+].CO>[Fe].O>[CH2:1]([N:8]1[CH2:15][CH:14]([NH2:16])[C:10]2([CH2:13][O:12][CH2:11]2)[CH2:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Komponenten

6

Edukt 3

HCID 887MethanolHCID 25517Ammonium ChlorideHCID 712547596-Benzyl-8-nitro-2-oxa-6-aza-spiro[3.4]octane

Produkt 1

HCID 712545836-Benzyl-2-oxa-6-azaspiro[3.4]octan-8-amine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23925IronKatalysatorHCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

The mixture of 6-benzyl-8-nitro-2-oxa-6-aza-spiro[3.4]octane (2 g, 8.1 mmol), iron powder (2.3 g, 40.5 mmol), ammonium chloride (4.3 g, 81 mmol), methanol (40 mL) and 8 mL of water was heated with stirring for 2 hours at 80° C. The reaction mixture was filtered by a pad of celite. The filtrate was concentrated under reduced pressure, and the residue was used for next step without further purification.

Aufarbeitung

  1. temperaturewas heated
  2. filtrationThe reaction mixture was filtered by a pad of celite
  3. concentrationThe filtrate was concentrated under reduced pressure
  4. customthe residue was used for next step without further purification

Quellen und Nachweise

ORD-Eintrag
ord-b79e12d3f2d847fa9d2aefa188457128
Quelldatensatz
uspto-grants-2014_10
Patentnummer
US08871756B2

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