Dimethylformamide → methyl 4-methyl-9-oxo-9H-fluorene-2-carboxylate

Under anhydrous calcium chloride drying conditions, 4-methyl-9-oxo-9H-fluorene-2-carboxylic acid (1.745 g), potassium carbonate (3.03 g) and dimethylformamide (20 ml) were mixed. To this mixture was added methyl iodide (0.92 ml) at room temperature, and the mixture was stirred for 3 hr 15 min. To the reaction mixture was added water (60 ml), and the mixture was stirred at room temperature for 30 min. The mixture was filtered and the obtained solid was air-dried and dried under reduced pressure at 80° C. to give the title compound (1.778 g, 96%).

1. stirringthe mixture was stirred at room temperature for 30 min
2. filtrationThe mixture was filtered
3. customthe obtained solid was air-dried
4. customdried under reduced pressure at 80° C.

ORD-Eintrag

ord-5c93f162cac6468881f8fa88d7478290

Quelldatensatz

uspto-grants-2014_10

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US08871934B2