Hydrazine hydrate (1:1) → 2-(Tetrahydrofuran-2-yl)acetohydrazide

HRID 541260Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 541260
[O:1]1[CH2:5][CH2:4][CH2:3][CH:2]1[CH2:6][C:7]([O:9]CC)=O.[NH2:12][NH2:13].O>C(O)C>[O:1]1[CH2:5][CH2:4][CH2:3][CH:2]1[CH2:6][C:7]([NH:12][NH2:13])=[O:9]

Komponenten

4

Edukt 2

HCID 24654Hydrazine hydrate (1:1)HCID 551345Ethyl Tetrahydrofuran-2-acetate

Produkt 1

HCID 607781292-(Tetrahydrofuran-2-yl)acetohydrazide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

To a round-bottom flask was added a solution of ethyl 2-(tetrahydrofuran-2-yl)acetate (2.00 g, 12.6 mmol, 1.00 equiv) in ethanol (20 mL). NH2NH2.H2O (1.27 g, 25.4 mmol, 2.00 equiv) was added to the reaction. The resulting solution was stirred overnight at 80° C. in an oil bath, then cooled to room temperature and concentrated in vacuo. This resulted in 2.10 g (92%) of 2-(tetrahydrofuran-2-yl)acetohydrazide as a yellow oil.

Aufarbeitung

  1. temperaturecooled to room temperature
  2. concentrationconcentrated in vacuo
  3. customThis resulted in 2.10 g (92%) of 2-(tetrahydrofuran-2-yl)acetohydrazide as a yellow oil

Quellen und Nachweise

ORD-Eintrag
ord-fd7e36a49ee94c47a871bf7e7cfaa5c4
Quelldatensatz
uspto-grants-2014_10
Patentnummer
US08871790B2

Notizen zur Reaktion

Wird geladen…