Sodium Iodide → t-Butyl methyl 7-iodoheptylmalonate

HRID 5414

Reaktionsgleichung

Reaktionsgleichung von HRID 5414
Br[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH:9]([C:17]([O:19][CH3:20])=[O:18])[C:10]([O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:11].[I-:21].[Na+]>CC(C)=O>[I:21][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH:9]([C:17]([O:19][CH3:20])=[O:18])[C:10]([O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:11]

Komponenten

4

Edukt 2

HCID 5238Sodium IodideHCID 19930816t-Butyl methyl 7-bromoheptylmalonate

Produkt 1

HCID 19930825t-Butyl methyl 7-iodoheptylmalonate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

t-Butyl methyl 7-bromoheptylmalonate (8.81 g, 25.1 mmol) is dissolved in acetone (50 ml). Sodium iodide (3.7 g, 25.1 mmol) is added and the mixture is stirred at reflux for 2 hours. The reaction mixture is filtered and the filtrate is concentrated to dryness. The residue is dissolved in methylene chloride and filtered again. The filtrate is concentrated to dryness to give t-butyl methyl 7-iodoheptylmalonate as an oil.

Aufarbeitung

  1. temperatureat reflux for 2 hours
  2. filtrationThe reaction mixture is filtered
  3. concentrationthe filtrate is concentrated to dryness
  4. dissolutionThe residue is dissolved in methylene chloride
  5. filtrationfiltered again
  6. concentrationThe filtrate is concentrated to dryness

Quellen und Nachweise

ORD-Eintrag
ord-2f96668fb4f34f4cb203add2e1dbf0d7
Quelldatensatz
uspto-grants-1993_09
Patentnummer
US05244889

Verknüpfte Notizen

Wird geladen…