methyl 1-methyl-5-nitro-1H-pyrazole-3-carboxylate → methyl 5-amino-1-methyl-1H-pyrazole-3-carboxylate
Reaktionsgleichung
[CH3:1][N:2]1[C:6]([N+:7]([O-])=O)=[CH:5][C:4]([C:10]([O:12][CH3:13])=[O:11])=[N:3]1>CO.[Pd]>[NH2:7][C:6]1[N:2]([CH3:1])[N:3]=[C:4]([C:10]([O:12][CH3:13])=[O:11])[CH:5]=1Komponenten
4
Edukt 1
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 2
Versuchsvorschrift
To a solution of methyl 1-methyl-5-nitro-1H-pyrazole-3-carboxylate (351.2, 0.48 g, 2.60 mmol) in MeOH (15 ml) under nitrogen was added palladium on carbon (10%, 0.25 g). The flask was further degassed with nitrogen and filled with H2 through a balloon. The mixture was stirred at room temperature for 1.5 hours. After purging the system with nitrogen, the reaction mixture was filtered through a Celite cake and concentrated to give 363 mg (90%) of a white solid. m/z (ES+) 156 (M+H)+.