HCID 57962249, Verbindung → tert-Butyl (3-{[(3-aminophenyl)acetyl]amino}phenyl)carbamate

HRID 541835Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 541835
[N+:1]([C:4]1[CH:5]=[C:6]([CH2:10][C:11]([NH:13][C:14]2[CH:15]=[C:16]([NH:20][C:21](=[O:27])[O:22][C:23]([CH3:26])([CH3:25])[CH3:24])[CH:17]=[CH:18][CH:19]=2)=[O:12])[CH:7]=[CH:8][CH:9]=1)([O-])=O.[H][H]>CO.[Pd]>[NH2:1][C:4]1[CH:5]=[C:6]([CH2:10][C:11]([NH:13][C:14]2[CH:15]=[C:16]([NH:20][C:21](=[O:27])[O:22][C:23]([CH3:25])([CH3:24])[CH3:26])[CH:17]=[CH:18][CH:19]=2)=[O:12])[CH:7]=[CH:8][CH:9]=1

Komponenten

5

Edukt 2

HCID 57962249HCID 57962249, VerbindungHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 57962170tert-Butyl (3-{[(3-aminophenyl)acetyl]amino}phenyl)carbamateAusbeute 94 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

To a solution of tert-butyl (3-{[(3-nitrophenyl)acetyl]amino}phenyl)carbamate (0.35 g, 0.94 mmol) in methanol (100 mL) was added 10% palladium on carbon (1:10, Palladium:carbon black, 0.15 g, 0.13 mmol). The reaction was shaken under 60 psi hydrogen gas overnight. The crude mixture was filtered through celite and concentrated under vacuum to give the desired product (0.30 g, 94%). LCMS for C19H23N3O3 (M-tBu+H)+: m/z=286.0.

Aufarbeitung

  1. filtrationThe crude mixture was filtered through celite
  2. concentrationconcentrated under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-270278be8ca946d49928fcfffd8b94e5
Quelldatensatz
uspto-grants-2014_10
Patentnummer
US08871753B2

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