HCID 57961596, Verbindung → tert-Butyl {2-[2-(3-aminophenyl)ethyl]pyridin-4-yl}carbamate

HRID 541842Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 541842
[NH2:1][C:2]1[CH:3]=[C:4]([C:8]#[C:9][C:10]2[CH:15]=[C:14]([NH:16][C:17](=[O:23])[O:18][C:19]([CH3:22])([CH3:21])[CH3:20])[CH:13]=[CH:12][N:11]=2)[CH:5]=[CH:6][CH:7]=1>CO.[Pd]>[NH2:1][C:2]1[CH:3]=[C:4]([CH2:8][CH2:9][C:10]2[CH:15]=[C:14]([NH:16][C:17](=[O:23])[O:18][C:19]([CH3:21])([CH3:20])[CH3:22])[CH:13]=[CH:12][N:11]=2)[CH:5]=[CH:6][CH:7]=1

Komponenten

4

Edukt 1

HCID 57961596HCID 57961596, Verbindung

Produkt 1

HCID 57962008tert-Butyl {2-[2-(3-aminophenyl)ethyl]pyridin-4-yl}carbamateAusbeute 95 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

To a mixture of tert-butyl {2-[(3-aminophenyl)ethynyl]pyridin-4-yl}carbamate (250 mg, 1.62 mmol) (prepared in Example C12, step A) in methanol (10 mL) was added 10% palladium on carbon (0.30 g, 0.24 mmol). The reaction mixture was hydrogenated at 50 psi overnight. The resultant mixture was filtered and concentrated to provide the desired product (240 mg, 95%) as a white solid. LCMS for C18H24N3O2 (M+H)+: m/z=314.0.

Aufarbeitung

  1. customwas hydrogenated at 50 psi overnight
  2. filtrationThe resultant mixture was filtered
  3. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-9260dea853494d6cb6f944618256c05a
Quelldatensatz
uspto-grants-2014_10
Patentnummer
US08871753B2

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